Is CYP2D6 phenotype predictable from CYP2D6 genotype?
نویسندگان
چکیده
منابع مشابه
CYP2D6 phenotype prediction from genotype: which system is the best?
Genotyping of the polymorphic cytochrome P450 (CYP) 2D6 gene is used increasingly in clinical practice. Several psychiatric hospitals already use CYP2D6 testing before treating a patient with antidepressant or antipsychotic drug therapy. In other fields of drug therapy, such as for breast cancer, CYP2D6 status has been reported to be an independent predictor for the outcome with tamoxifen. Thus...
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BACKGROUND Genotypes of the drug-metabolizing enzyme CYP2D6 influence plasma levels of 25% of commonly prescribed drugs. This is the first study in India to investigate the genotype-phenotype relationship of CYP2D6. AIM To study the influence of some CYP2D6 genotypes on the metabolism of its substrate dextromethorphan in healthy South Indian volunteers and to assess the contribution of the CY...
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The CYP2D6 enzyme metabolizes a quarter of all prescribed drugs, including codeine. Some individuals have multiple functional copies of the CYP2D6 gene, making them “ultrarapid metabolizers”. They are able to metabolize codeine to morphine more rapidly and more completely. As a result, even with normal doses of codeine, these individuals may experience the symptoms of morphine overdose, which i...
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The CYP2D6 enzyme metabolizes a quarter of all prescribed drugs, and is one of the main enzymes responsible for converting tamoxifen into its active metabolites. Individuals who carry two nonfunctioning copies of CYP2D6 are known as poor metabolizers. Individuals who carry one or two decreased activity alleles are referred to as intermediate metabolizers. Importantly, there are also heterozygou...
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Polymorphic CYP2D6 is the enzyme that activates the opioid analgesic tramadol by O-demethylation to its active metabolite O-demethyltramadol (M1). Our objective was to determine the opioid effects measured by pupillary response to tramadol of CYP2D6 genotyped volunteers in relation to the disposition of tramadol and M1 in plasma. Tramadol displayed phenotypic pharmacokinetics and it was possibl...
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ژورنال
عنوان ژورنال: Microchemical Journal
سال: 2018
ISSN: 0026-265X
DOI: 10.1016/j.microc.2016.10.018